I've been doing web design for years and have been stuck with the good old web safe fonts. By creating your page in web safe fonts you can be assured that all browsers on all operating systems will be able to render your page. I know how important accessability is, but after a few years the same fonts gets boring... "Do I want to use Verdana or Arial on this page?" Sure, you can use graphics for other fonts but that will ruin SEO and access efforts, so it should be used minimally. This leaves web designers stuck in a rut... your design has to use certain fonts or be non-compliant to standards. What is a creative designer to do?
Typekit is not yet released but it looks extremely interesting. The guys over at typekit are building a "nimble, safe tool that makes it easier for web designers to do amazing design online..."
Typography is really an area that has been lacking in web design, so it will be amazing to finally break through that barrier. Now comes the problem that print designers run into - which font out of these 6,000 should I use for this page? I guess every breakthrough makes your life a bit more complicated.